Effects of phenobarbital on biliary excretion of organic acids in male and female rats.

HART, LARRY G., ANTHONY M. GUARINO, AND RICHARD H, ADAMSON. Effects of phenobarbital on biliary excretion of organic acids 2*lz male and female rats. Am. J. Physiol. 2 17( 1) : 46-52. 1969.-The effects of phenobarbital pretreatment on the biliary excretion of four organic anions, indocyanine green (ICG), chlorothiazide (CTZ), phenol red, and probenecid, were investigated. Indocyanine green and CT2 are not metabolized in the rat, whereas phenol red and probenecid are excreted into the bile largely as glucuronides. Phenobarbital-pretreated male rats excreted more ICG and probenecid, but not more phenol red or CTZ, than controls. Females pretreated with phenobarbital excreted more CT2 and probenecid, but not greater amounts of ICG or phenol red. In the induced animals the glucuronides of phenol red and probenecid were not excreted in greater amounts than in control animals. Where increased biliary excretion of these compounds were observed, it was concluded to be due primarily to the increased bile flow in phenobarbital-treated animals.